BDBM50124868 CHEMBL3622958

SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(C)c3c2)n1

InChI Key InChIKey=WVDKJJLIGILVRJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50124868   

TargetTyrosine-protein kinase SYK(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50: 1.70nMT: 2°CAssay Description:Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50: 56nMAssay Description:Inhibition of SYK-mediated TNFalpha production in human IgG-stimulated human THP1 cells incubated for 18 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of human ERG by manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50: 9.96E+5nMT: 2°CAssay Description:Inhibition of purified full-length human ZAP70 pre-incubated for 30 mins at room temperature before UlighTM-PolyGT peptide substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50: 1.38E+5nMT: 2°CAssay Description:Inhibition of human JAK2 pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate addition by cell f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50: 418nMT: 2°CAssay Description:Inhibition of JAK3 (unknown origin) pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50: 985nMT: 2°CAssay Description:Inhibition of Aurora B kinase (unknown origin) pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124868(CHEMBL3622958)
Affinity DataIC50: 653nMT: 2°CAssay Description:Inhibition of KDR (unknown origin) pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed