BDBM50130549 CHEMBL3632711

SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)N)c2ccc(c3c2cccc3)N(CC(=O)N)S(=O)(=O)c4ccc(cc4)OC

InChI Key InChIKey=ZUIXHSIMKQZYPV-UHFFFAOYSA-N

Data  1 KI  3 IC50  4 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50130549   

TargetKelch-like ECH-associated protein 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataIC50: 44nMAssay Description:Binding affinity to the Keap1 (321 to 609 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by surface plasmon resonance assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataIC50: 63nMAssay Description:Inhibition of Keap1 Kelch domain (unknown origin) /Nrf2 (unknown origin) interaction using fluorescein-labeled 9-mer peptide containing NRF2 Neh2 dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataKd:  44nMAssay Description:Binding affinity to Keap1 Kelch domain (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataKd:  190nMAssay Description:Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataEC50:  1.20E+4nMAssay Description:Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) assessed as thermal stabiliza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataKd:  44nMAssay Description:Binding affinity to human KEAP1 by SPR direct binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataIC50: 63nMAssay Description:Inhibition of human Keap1-Nrf2 protein-protein interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataKd:  169nMAssay Description:Inhibition of Keap1-Nrf2 protein-protein interaction (unknown origin) measured after 60 mins by FITC-betaAla-DEETGEF-OH probe based fluorescent polar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataKi:  53nMAssay Description:Inhibition of Cys5-LDEETGEFL-NH2 binding to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)