BDBM50136579 CHEMBL3754781

SMILES c1ccc(cc1)C[C@@H](C(=O)NCCc2cc(ccc2n3cnnn3)Cl)NC(=O)c4ccc5c(c4)C(=CC(=O)N5)O

InChI Key InChIKey=JAUUPTJHJIUVMZ-UHFFFAOYSA-N

Data  12 KI

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50136579   

TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human coagulation factor 11a assessed as substrate hydrolysis to p-nitroaniline incubated for 10 to 120 mins by spectrophotometry analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlasma kallikrein(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi:  110nMAssay Description:Inhibition of human plasma kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed
TargetTrypsin(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi: >6.20E+3nMAssay Description:Inhibition of human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi: >9.00E+3nMAssay Description:Inhibition of human coagulation factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition of human coagulation factor 7aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi: >2.80E+4nMAssay Description:Inhibition of human coagulation factor 12aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi: >2.80E+4nMAssay Description:Inhibition of human urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human tissue kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi: >4.60E+4nMAssay Description:Inhibition of human tissue plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi: >6.40E+4nMAssay Description:Inhibition of human activated protein CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed
TargetCoagulation factor IX(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136579(CHEMBL3754781)
Affinity DataKi: >7.30E+4nMAssay Description:Inhibition of human coagulation factor 9aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMed