BDBM50139604 1-(5-tert-Butyl-isoxazol-3-yl)-3-[4-(pyridin-4-yloxy)-phenyl]-urea::1-(5-tert-butylisoxazol-3-yl)-3-(4-(pyridin-4-yloxy)phenyl)urea::CHEMBL166031

SMILES CC(C)(C)c1cc(no1)NC(=O)Nc2ccc(cc2)Oc3ccncc3

InChI Key InChIKey=XKNAGLMNQADBQE-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50139604   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50139604(1-(5-tert-Butyl-isoxazol-3-yl)-3-[4-(pyridin-4-ylo...)
Affinity DataIC50: 230nMAssay Description:Inhibitory activity against human Raf-1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50139604(1-(5-tert-Butyl-isoxazol-3-yl)-3-[4-(pyridin-4-ylo...)
Affinity DataIC50: 63nMAssay Description:Inhibition of full-length FLAG-6His-TEV tagged human RIP2 expressed in Sf9 cells assessed as reduction in autophosphorylation pre-incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50139604(1-(5-tert-Butyl-isoxazol-3-yl)-3-[4-(pyridin-4-ylo...)
Affinity DataIC50: 320nMAssay Description:Inhibition of full-length FLAG-6His-TEV tagged human RIP2 expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50139604(1-(5-tert-Butyl-isoxazol-3-yl)-3-[4-(pyridin-4-ylo...)
Affinity DataIC50: 230nMAssay Description:Inhibition of Raf-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50139604(1-(5-tert-Butyl-isoxazol-3-yl)-3-[4-(pyridin-4-ylo...)
Affinity DataIC50: 230nMAssay Description:Inhibition of CRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50139604(1-(5-tert-Butyl-isoxazol-3-yl)-3-[4-(pyridin-4-ylo...)
Affinity DataIC50: 230nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed