BDBM50147086 8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMIDE::CHEMBL103043

SMILES c1cc2ccc(cc2c(c1)Nc3ncccn3)C(=N)N

InChI Key InChIKey=GRQLDCHTDNYVQI-UHFFFAOYSA-N

Data  8 KI

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50147086   

TargetUrokinase-type plasminogen activator(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147086(8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMI...)
Affinity DataKi:  30nMAssay Description:Binding affinity towards Urokinase-type plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147086(8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMI...)
Affinity DataKi:  32nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147086(8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMI...)
Affinity DataKi:  35nMAssay Description:Binding affinity towards Urokinase-type plasminogen activator (urokinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKallikrein-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50147086(8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMI...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity towards P-kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50147086(8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMI...)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50147086(8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMI...)
Affinity DataKi:  3.20E+3nMAssay Description:Binding affinity against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50147086(8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMI...)
Affinity DataKi:  3.80E+3nMAssay Description:Binding affinity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50147086(8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMI...)
Affinity DataKi:  2.40E+4nMAssay Description:Binding affinity towards tissue type plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed