BDBM50172078 LY-2801653::Merestinib::US11952364, Example Merestinib

SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1

InChI Key InChIKey=QHADVLVFMKEIIP-UHFFFAOYSA-N

Data  2 KI  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50172078   

TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human full length AXL by scintillation counting method in presence of 33P-gammaATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Tanta University

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 19nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED

US Patent
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 1.00E+4nMAssay Description:Human liver microsome solution prepared according to the following table (diluted with potassium phosphate solution) Protein con. of working Final pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2024
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED

US Patent
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 1.00E+4nMAssay Description:Human liver microsome solution prepared according to the following table (diluted with potassium phosphate solution) Protein con. of working Final pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2024
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED

US Patent
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 1.00E+4nMAssay Description:Human liver microsome solution prepared according to the following table (diluted with potassium phosphate solution) Protein con. of working Final pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2024
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED

US Patent
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 4.20E+3nMAssay Description:Human liver microsome solution prepared according to the following table (diluted with potassium phosphate solution) Protein con. of working Final pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2024
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED

US Patent
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 1.00E+4nMAssay Description:Human liver microsome solution prepared according to the following table (diluted with potassium phosphate solution) Protein con. of working Final pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2024
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Tanta University

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Wellmarkerbio Co.

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 12nMAssay Description:Inhibition of RON (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Tanta University

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 109nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 130nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Tanta University

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of cMET (unknown origin) by FISH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Wellmarkerbio Co.

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of RON (unknown origin) by FISH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length AXL after 4 hrs followed by stimulation with human recombinant Gas6 for 15 minutes by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Tanta University

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Tanta University

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed