BDBM50179869 CHEMBL203682::N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-benzenesulfonamide

SMILES CN(c1ccc(cc1)C(C(F)(F)F)(C(F)(F)F)O)S(=O)(=O)c2ccccc2

InChI Key InChIKey=CNVKZYLQZYULJV-UHFFFAOYSA-N

Data  2 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50179869   

TargetOxysterols receptor LXR-beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50179869(N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzenesulfonamide from LXRbeta by scintillation proximity assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxysterols receptor LXR-alpha(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50179869(N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Affinity DataEC50:  200nMAssay Description:Activity against LXR alpha transiently transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50179869(N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Affinity DataIC50: 40nMAssay Description:Displacement of [3H]N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzenesulfonamide from LXRalpa by scintillation proximity assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50179869(N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Affinity DataEC50:  3.76E+3nMAssay Description:Agonist activity against human LXRalpha expressed in human HEK293T cells co-expressing CMX-GAL4N-hLXRalpha incubated for 24 hrs by reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50179869(N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Affinity DataEC50:  2.93E+3nMAssay Description:Agonist activity against human LXRbeta expressed in human HEK293T cells co-expressing CMX-GAL4N-hLXRbeta incubated for 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)