BDBM50188961 CHEMBL3622533

SMILES COc1ccc(cn1)-c1nc(N2CCOCC2)c2sc(CN(C)c3ncc(cn3)C(=O)NO)cc2n1

InChI Key InChIKey=JOWXJLIFIIOYMS-UHFFFAOYSA-N

Data  92 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 93 hits for monomerid = 50188961   

TargetHistone deacetylase 11(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC11 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of N-terminal FLAG-tagged human HDAC10 (2 to 631 residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 639nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 54nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 528nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate 3 measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 581nMAssay Description:Inhibition of HDAC5 (unknown origin) using fluorogenic HDAC class2a as substrate measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 479nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged and C-terminal His-tagged HDAC4 (627 to 1084 end residues) expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC3 (1 to 428 end residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residue...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 8nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorogenic HDAC substrate 3 incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 end residues) expressed in baculovirus infected Sf9 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human PI3Kdelta incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of human full length HDAC11 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as substrate measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC10 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 27nMAssay Description:Inhibition of HDAC6 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 554nMAssay Description:Inhibition of HDAC9 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 426nMAssay Description:Inhibition of HDAC7 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 674nMAssay Description:Inhibition of HDAC5 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 409nMAssay Description:Inhibition of HDAC4 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 191nMAssay Description:Inhibition of HDAC8 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC3 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC2 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC1 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 554nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HDAC1 (unknown origin) by color-de-lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 177nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 27nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 39nMAssay Description:Inhibition of PI3K-gamma (unknown origin) by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 54nMAssay Description:Inhibition of PI3K-beta (unknown origin) by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 19nMAssay Description:Inhibition of PI3K-alpha (unknown origin) by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HDAC1 derived from human HeLa nuclear extract using COLOR DE LYS substrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 191nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 39nMAssay Description:Inhibition of human PI3K delta by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 54nMAssay Description:Inhibition of human PI3K beta by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 19nMAssay Description:Inhibition of human PI3K alpha by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 7.95E+4nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PIK3C3 incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 3.67E+3nMAssay Description:Inhibition of human DNA-PKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 185nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 112nMAssay Description:Inhibition of human PI3Kgamma incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 21nMAssay Description:Inhibition of human PI3Kbeta incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human PI3Kalpha incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 191nMAssay Description:Inhibition of full length C-terminal His-tagged human recombinant HDAC8 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged PI3K p110alpha/untagged p85alpha expressed in baculovirus infected insect Sf9 cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 54nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged PI3K p110beta/untagged p85alpha expressed in baculovirus infected insect Sf9 cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
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