BDBM50207594 2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfonic acid amide::2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline::2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline::3-Hydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxalin-2-ol anion::6-Nitro-2,3-dioxo-1,2,3,4,4a,10b-hexahydro-benzo[f]quinoxaline-7-sulfonic acid amide::6-Nitro-2,3-dioxo-1,2,3,4-tetrahydro-benzo[f]quinoxaline-7-sulfinic acid amide::6-Nitro-2,3-dioxo-1,2,3,4-tetrahydro-benzo[f]quinoxaline-7-sulfonic acid amide::6-Nitro-2,3-dioxo-2,3-dihydro-benzo[f]quinoxaline-7-sulfonic acid amide::6-nitro-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide::CHEMBL222519

SMILES c1cc2c(c(c1)S(=O)(=O)N)c(cc3c2NC(=O)C(=O)N3)[N+](=O)[O-]

InChI Key InChIKey=UQNAFPHGVPVTAL-UHFFFAOYSA-N

Data  13 KI  13 IC50  2 Kd

PDB links: 6 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50207594   

TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 1.00E+5nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 7.40E+4nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 3.70E+4nMAssay Description:Antagonist activity at human recombinant GLUK5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 2.90E+4nMAssay Description:Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 2.50E+3nMAssay Description:Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKd:  1.78E+3nMAssay Description:Antagonism on GLUK5 containing kainate induced depolarization of isolated neonatal rat dorsal root C-fibersMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 4.40E+4nMAssay Description:Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 1.00E+5nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in HEK293 cells expressing human GLUA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, kainate 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in HEK293 cells expressing human GLUK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in HEK293 cells expressing human GLUA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 3(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in HEK293 cells expressing human GLUA3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in HEK293 cells expressing human GLUA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, kainate 5(Rat)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKd:  1.78E+3nMAssay Description:Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibersMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in HEK293 cells expressing human GLUK5 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  210nMAssay Description:Inhibition of [3H]-AMPA binding to human GluR2 receptors expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  260nMAssay Description:Ability to displace binding of [3H]AMPA to recombinant human Ionotropic glutamate receptor AMPA 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 4(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  600nMAssay Description:Ability to displace binding of [3H]AMPA to recombinant human Ionotropic glutamate receptor AMPA 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  900nMAssay Description:Ability to displace binding of [3H]AMPA to recombinant human Ionotropic glutamate receptor AMPA 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  1.60E+3nMAssay Description:Ability to displace binding of [3H]AMPA to recombinant human Ionotropic glutamate receptor AMPA 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, kainate 1(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  1.17E+4nMAssay Description:Inhibition of [3H]-KA binding to iontropic glutamate receptor 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  1.32E+4nMAssay Description:Ability to displace binding of [3H]AMPA to recombinant human AMPA receptor Ionotropic glutamate receptor ionotropic kainate 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  1.32E+4nMAssay Description:Inhibition of [3H]KA binding to iontropic glutamate receptor 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  1.80E+4nMAssay Description:Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  3.30E+4nMAssay Description:Ability to displace [3H]glycine from NMDA receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi:  3.30E+4nMAssay Description:Compound was tested for binding affinity against glycine site of NMDA receptor using [3H]glycine as a radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGlutamate receptor ionotropic, kainate 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi: >1.00E+5nMAssay Description:Ability to displace binding of [3H]KA to recombinant human KA receptor Ionotropic glutamate receptor ionotropic kainate 2 expressed in EK 293 cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50207594(2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxali...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards glycine binding site on NMDA receptor was determined in rat whole brain membrane using strychnine-insensitive [3H]Gly as rad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed