BindingDB BDBM50208911 CHEMBL3884319

BDBM50208911 CHEMBL3884319

SMILES CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3ccccc3)ncc12

InChI Key InChIKey=XLFNLJYGUOLEJS-UHFFFAOYSA-N

Data 100 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 100 hits for monomerid = 50208911

High affinity nerve growth factor receptor(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 494nMAssay Description:Inhibition of human recombinant His-tagged NTRK1 cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

MAP/microtubule affinity-regulating kinase 3(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.20nMAssay Description:Inhibition of full length human MARK3 using biotin labeled peptide substrate by HTRF based assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

RAC-alpha serine/threonine-protein kinase(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged AKT1alpha expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Epidermal growth factor receptor(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Serine/threonine-protein kinase Nek6(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length GST-tagged NEK6 expressed in insect expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Mitogen-activated protein kinase 8(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged MAPK8 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

cAMP-dependent protein kinase catalytic subunit alpha(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant His-tagged PRKACA catalytic domain (1 to 351 residues) expressed in Escherichia coliMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

NUAK family SNF1-like kinase 1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 5nMAssay Description:Inhibition of human recombinant full length His-tagged NUAK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Interleukin-1 receptor-associated kinase 1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged IRAK1 catalytic domain (194 to 712 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Beta-adrenergic receptor kinase 1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged ADRBK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Tyrosine-protein kinase HCK(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.86E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged HCK cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Tyrosine-protein kinase Lck(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 818nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged LCK cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Ribosomal protein S6 kinase beta-1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged RPS6KB1 cytoplasmic domain (1 to 421 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

MAP/microtubule affinity-regulating kinase 4(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 21nMAssay Description:Inhibition of human MARK4 expressed in HEK293T cells coexpressing tau protein assessed as reduction in tau phosphorylation at Ser262 residues by Alph...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Aurora kinase B(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 163nMAssay Description:Inhibition of human recombinant full length His-tagged AURKB expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

NT-3 growth factor receptor(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 157nMAssay Description:Inhibition of human recombinant His-tagged NTRK3 cytoplasmic domain (510 to 825 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Mast/stem cell growth factor receptor Kit(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 76nMAssay Description:Inhibition of human recombinant His-tagged KIT cytoplasmic domain (544 to 976 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Receptor-type tyrosine-protein kinase FLT3(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 8nMAssay Description:Inhibition of human recombinant His-tagged FLT3 cytoplasmic domain (564 to 958 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

SRSF protein kinase 1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged SRPK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Glycogen synthase kinase-3 alpha(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 3.31E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged GSK3A expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Serine/threonine-protein kinase pim-1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged PIM1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Sphingosine kinase 1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length GST-tagged SPHK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged PIK3 P110D/P85A expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Serine/threonine-protein kinase TAO2(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged TAOK2 cytoplasmic domain (1 to 314 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Lysine--tRNA ligase(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged SYK cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Mitogen-activated protein kinase 13(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged MAPK13 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Serine/threonine-protein kinase MRCK alpha(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant His-tagged CDC42BPA catalytic domain (1 to 473 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Cyclin-dependent kinase 2(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 605nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Proto-oncogene tyrosine-protein kinase Src(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 668nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged SRC cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 206nMAssay Description:Inhibition of human recombinant full length N-terminal GST/N-terminal His-tagged AMPK alpha2/beta1/gamma1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Serine/threonine-protein kinase PAK 1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length GST-tagged PAK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Ephrin type-B receptor 2(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 2.16E+3nMAssay Description:Inhibition of human recombinant GST-tagged EPHB2 cytoplasmic domain (616 to 884 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Ribosomal protein S6 kinase alpha-3(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 692nMAssay Description:Inhibition of human recombinant full length His-tagged RPS6KA3 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Mitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length GST-tagged MAPK14alpha expressed in Escherichia coliMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Serine/threonine-protein kinase Nek4(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length GST-tagged NEK4 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Rho-associated protein kinase 1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged ROCK1 cytoplasmic domain (1 to 535 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Protein kinase C iota type(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged PRKCI expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Serine/threonine-protein kinase Nek2(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Serine/threonine-protein kinase Sgk1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged SGK cytoplasmic domain (60 to 431 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Tyrosine-protein kinase ITK/TSK(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length GST-tagged ITK cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Ephrin type-A receptor 8(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged EPHA8 cytoplasmic domain (565 to 1005 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Casein kinase I isoform alpha(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length GST-tagged CSNK1A1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

RAC-gamma serine/threonine-protein kinase(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged AKT3gamma expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Ephrin type-A receptor 3(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 2.09E+3nMAssay Description:Inhibition of human recombinant His-tagged EPHA3 cytoplasmic domain (569 to 976 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Mitogen-activated protein kinase 1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.83E+3nMAssay Description:Inhibition of human recombinant full length GST-tagged MAPK1 expressed in Escherichia coliMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Hepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 1.25E+3nMAssay Description:Inhibition of human recombinant N-terminal His-tagged MET cytoplasmic domain (956 to 1390 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 793nMAssay Description:Inhibition of human recombinant full length His-tagged CDK7/cyclin H/MNAT1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Cyclin-dependent kinase 5 activator 1(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 658nMAssay Description:Inhibition of human recombinant full length GST/His-tagged CDK5/P25 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Leucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 167nMAssay Description:Inhibition of human full length wild type DYKDDDDK-tagged LRRK2 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Merck

Curated by ChEMBL

BDBM50208911(CHEMBL3884319)

IC50: 136nMAssay Description:Inhibition of human recombinant full length His-tagged PDK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Date in BDB:
9/3/2018
Entry Details Article
PubMed

Displayed 1 to 50 (of 100 total ) | Next | Last >>

Filter my 100 hits

Targets 100▿
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 1
- Tyrosine-protein kinase JAK1 1
- Receptor tyrosine-protein kinase erbB-2 1
- Lysine--tRNA ligase 1
- Hepatocyte growth factor receptor 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Serine/threonine-protein kinase B-raf 1
- Glycogen synthase kinase-3 alpha 1
- Glycogen synthase kinase-3 beta 1
- Serine/threonine-protein kinase Nek6 1
- Protein kinase C iota type 1
- NUAK family SNF1-like kinase 1 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek2 1
- Sphingosine kinase 1 1
- MAP/microtubule affinity-regulating kinase 3 1
- Serine/threonine-protein kinase PAK 1 1
- Protein kinase C theta type 1
- Tyrosine-protein kinase JAK3 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Tyrosine-protein kinase JAK2 1
- MAP/microtubule affinity-regulating kinase 4 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Tyrosine-protein kinase ZAP-70 1
- Leucine-rich repeat serine/threonine-protein kinase 2 1
- Serine/threonine-protein kinase Sgk1 1
- Ephrin type-A receptor 3 1
- Tyrosine-protein kinase BTK 1
- Tyrosine-protein kinase ITK/TSK 1
- Insulin-like growth factor 1 receptor 1
- Epidermal growth factor receptor 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Ribosomal protein S6 kinase beta-1 1
- Serine/threonine-protein kinase 26 1
- Cyclin-dependent kinase 2 1
- Ephrin type-B receptor 2 1
- MAP kinase-activated protein kinase 2 1
- Ephrin type-A receptor 8 1
- MAP kinase-activated protein kinase 5 1
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 1
- Death-associated protein kinase 1 1
- PAS domain-containing serine/threonine-protein kinase 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Beta-adrenergic receptor kinase 1 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase TAO2 1
- Testis-specific serine/threonine-protein kinase 1 1
- Angiopoietin-1 receptor 1
- Mast/stem cell growth factor receptor Kit 1
- Serine/threonine-protein kinase MRCK alpha 1
- Protein-tyrosine kinase 6 1
- Mitogen-activated protein kinase 14 1
- Activin receptor type-1B 1
- Casein kinase II subunit alpha 1
- Cyclin-dependent kinase 5 activator 1 1
- Interleukin-1 receptor-associated kinase 4 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- RAC-gamma serine/threonine-protein kinase 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1
- Interleukin-1 receptor-associated kinase 1 1
- Mitogen-activated protein kinase kinase kinase 8 1
- Tyrosine-protein kinase ABL1 1
- RAC-alpha serine/threonine-protein kinase 1
- Rho-associated protein kinase 2 1
- Rho-associated protein kinase 1 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Mitogen-activated protein kinase 1 1
- Tyrosine-protein kinase Lck 1
- CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 1
- NT-3 growth factor receptor 1
- Mitogen-activated protein kinase 9 1
- G protein-coupled receptor kinase 4 1
- Dual specificity protein kinase CLK2 1
- High affinity nerve growth factor receptor 1
- G protein-coupled receptor kinase 6 1
- Mitogen-activated protein kinase 8 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Serine/threonine-protein kinase N1 1
- Ribosomal protein S6 kinase alpha-3 1
- Serine/threonine-protein kinase TBK1 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- Aurora kinase B 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Tyrosine-protein kinase HCK 1
- Fibroblast growth factor receptor 2 1
- Serine/threonine-protein kinase PLK1 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Mitogen-activated protein kinase 13 1
- RAC-beta serine/threonine-protein kinase 1
- Casein kinase I isoform alpha 1
- Misshapen-like kinase 1 1
- Macrophage colony-stimulating factor 1 receptor 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Protein kinase C zeta type 1
- Serine/threonine-protein kinase Chk2 1
- Serine/threonine-protein kinase Chk1 1
- SRSF protein kinase 1 1
Publications 1▿
- Bioorg Med Chem Lett 27: 114-120 (2017) 100
Institutions 1▿
- Merck 100
Affinity: 1.2 to 1.0E+4 nM▿
- IC50 100
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0