BDBM50211642 CHEMBL397209::Methyl(1,2,3,6-tetrahydropyridinium-4-yl)phosphinate::methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid

SMILES CP(=O)(C1=CCNCC1)O

InChI Key InChIKey=MFUKVPOVVKKLRQ-UHFFFAOYSA-N

Data  3 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50211642   

TargetGamma-aminobutyric acid type B receptor subunit 1(Human)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50211642(methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic a...)
Affinity DataEC50:  5.00E+5nMAssay Description:Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50211642(methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic a...)
Affinity DataEC50:  5.00E+5nMAssay Description:Antagonist activity at human recombinant GABAb 1b/2 receptor expressed in Xenopus laevis oocytes co-expressing GIRK1/4 assessed as inhibition of GABA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50211642(methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic a...)
Affinity DataIC50: 2.21E+4nMAssay Description:Antagonist activity at human recombinant GABAc rho-2 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50211642(methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic a...)
Affinity DataIC50: 2.22E+3nMAssay Description:Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50211642(methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic a...)
Affinity DataIC50: 2.22E+3nMAssay Description:Antagonist activity at GABAC rho1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50211642(methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic a...)
Affinity DataEC50:  5.00E+5nMAssay Description:Inhibition of rat hippocampal Gamma-aminobutyric acid type B receptor (weak agonist)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article