BDBM50233520 Fevipiprant::NVP-QAW039::QAW039

SMILES Cc1c(c2cccnc2n1Cc3ccc(cc3C(F)(F)F)S(=O)(=O)C)CC(=O)O

InChI Key InChIKey=GFPPXZDRVCSVNR-UHFFFAOYSA-N

Data  1 KI  16 IC50  1 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50233520   

TargetProstaglandin F2-alpha receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at FP receptor (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
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TargetProstaglandin E2 receptor EP4 subtype(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at EP4 receptor (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
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TargetProstacyclin receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at IP receptor (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
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TargetThromboxane A2 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at TP receptor (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
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TargetProstaglandin E2 receptor EP3 subtype(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at EP3 receptor (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
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TargetProstaglandin D2 receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at DP2 receptor in CD4-positive human TH2 cells assessed as inhibition of DK-PGD2-induced IL-13 production after 6 to 8 hrsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetCytochrome P450 1A2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
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TargetProstaglandin D2 receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at DP2 receptor in human isolated eosinophils assessed as inhibition of DK-PGD2-induced shape change preincubated for 5 mins foll...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetProstaglandin D2 receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at DP2 receptor in human whole assessed as inhibition of DK-PGD2-induced eosinophils shape change preincubated for 5 mins followe...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetProstaglandin E2 receptor EP2 subtype(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at EP2 receptor (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMed
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TargetCytochrome P450 2D6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
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TargetProstaglandin E2 receptor EP3 subtype(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at EP3 receptor (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMed
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TargetProstaglandin D2 receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at DP2 receptor in CD4-positive human TH2 cells assessed as inhibition of DK-PGD2-induced IL-5 production after 6 to 8 hrsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetProstacyclin receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at IP receptor (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMed
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TargetCytochrome P450 2C9(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetProstaglandin D2 receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataKd:  1nMAssay Description:Displacement of [3H]NVP-QAW039 from human DP2 receptor expressed in CHO cell membranes by TopCount scintillation assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMed
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TargetProstaglandin D2 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at DP1 receptor (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMed
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TargetProstaglandin D2 receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at DP2 receptor in CD4-positive human TH2 cells assessed as inhibition of DK-PGD2-induced IL-5 production after 6 to 8 hrsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetProstaglandin D2 receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50233520(Fevipiprant | NVP-QAW039 | QAW039)Copy SMILESCopy InChI

Affinity DataKi:  4nMAssay Description:Displacement of [3H]PGD2 from human DP2 receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2019
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL