BDBM50234609 Cariporide::HOE-642

SMILES [#6]-[#6](-[#6])-c1ccc(cc1S([#6])(=O)=O)-[#6](=O)\[#7]=[#6](\[#7])-[#7]

InChI Key InChIKey=VJSKBONMJDSNGP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50234609   

TargetSodium/hydrogen exchanger 1(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50234609(Cariporide | HOE-642)
Affinity DataIC50: 172nMAssay Description:Inhibition of platelet NHE1 in human platelet rich plasma assessed as decrease in platelet swelling preincubated for 3 mins followed by sodium propio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 3(Rabbit)
Merck

Curated by ChEMBL
LigandPNGBDBM50234609(Cariporide | HOE-642)
Affinity DataIC50: 26nMAssay Description:Sodium/hydrogen exchanger antiport activity was measured using [22]Na+ uptake inhibition assay in acidified rabbit erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 3(Rabbit)
Merck

Curated by ChEMBL
LigandPNGBDBM50234609(Cariporide | HOE-642)
Affinity DataIC50: 26nMAssay Description:Inhibition of 5-N-(ethyl isopropyl)-amiloride[EIPA]-sensitive Na+ uptake into acidified rabbit erythrocytes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50234609(Cariporide | HOE-642)
Affinity DataIC50: 800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50234609(Cariporide | HOE-642)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50234609(Cariporide | HOE-642)
Affinity DataIC50: 0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed