BDBM50238860 CHEMBL4099219

SMILES O=c1c2c([nH]c(Cc3ccc4OCOc4c3)c2oc2ccccc12)-c1nccs1

InChI Key InChIKey=ZUGQSSCMJHOUMY-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50238860   

TargetCytochrome P450 2C19(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 6.22E+3nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) using [3H]cGMP or [3H]cAMP as substrate after 15 mins by liquid scintillation counting me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 153nMAssay Description:Inhibition of PDE10A (449 to 770 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (679 to 1087 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cAMP or [3H]cGMP as substrate after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 2.77E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cAMP or [3H]cGMP as substrate after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of CYP1A2 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 58nMAssay Description:Inhibition of PDE6A (484 to 817 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE9A2 (181 to 506 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE7A1 (130 to 482 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C8 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2B6 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 362nMAssay Description:Inhibition of PDE2A (580 to 919 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE1B (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cAMP or [3H]cGMP as substrate after 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2019
Entry Details Article
PubMed