BDBM50239942 CHEMBL4081869::US9872852, Example 37

SMILES COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CNCCNC(C)=O

InChI Key InChIKey=OYNIISWIMDFFAF-UHFFFAOYSA-N

Data  9 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50239942   

TargetProgrammed cell death 1 ligand 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239942(US9872852, Example 37 | CHEMBL4081869)
Affinity DataIC50: 6nMAssay Description:Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239942(US9872852, Example 37 | CHEMBL4081869)
Affinity DataKd: <1.00E+3nMAssay Description:Binding affinity to 15N-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) by 1H-15N 2D HMQC NMR spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239942(US9872852, Example 37 | CHEMBL4081869)
Affinity DataIC50: 53nMAssay Description:All binding studies were performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (withv) bovine serum albumin and 0.05% (v/v) Twe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetProgrammed cell death 1 ligand 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239942(US9872852, Example 37 | CHEMBL4081869)
Affinity DataIC50: 100nMAssay Description:Inhibition of PDL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239942(US9872852, Example 37 | CHEMBL4081869)
Affinity DataIC50: 1nMAssay Description:Binding affinity to PDL1 (unknown origin) assessed as reduction in PDL1/PD1 protein-protein interaction preincubated for 15 mins followed by PD1 addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239942(US9872852, Example 37 | CHEMBL4081869)
Affinity DataIC50: 100nMAssay Description:Inhibition of human PD-1/PDL1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239942(US9872852, Example 37 | CHEMBL4081869)
Affinity DataIC50: 83nMAssay Description:Inhibition of Tag2-PD-1/Tag1-PD-L1 (unknown origin) protein-protein interaction incubated for 15 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239942(US9872852, Example 37 | CHEMBL4081869)
Affinity DataIC50: 100nMAssay Description:Inhibition of PD-1-Ig/His-PD-L1 (unknown origin) protein-protein interaction incubated with PD-L1 for 15 mins followed by addition of PD-1 for 15 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239942(US9872852, Example 37 | CHEMBL4081869)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PD-1/PD-L1 interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239942(US9872852, Example 37 | CHEMBL4081869)
Affinity DataIC50: 6nMAssay Description:Inhibition of Ig-tagged PD-1 (unknown origin)/His-tagged PD-L1 (unknown origin) protein-protein interaction preincubated with PD-L1 for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed