BDBM50242271 (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol::(2R,3R,4R,5S)-1-ethoxy-2-(hydroxymethyl)piperidine-3,4,5-triol::BAY-M-1099::CHEMBL1561::Glyset::MIGLITOL::N-Hydroxyethyl-1-deoxynojirimycin::cid_441314

SMILES C1[C@@H]([C@H]([C@@H]([C@H]([N@@]1CCO)CO)O)O)O

InChI Key InChIKey=IBAQFPQHRJAVAV-UHFFFAOYSA-N

Data  4 KI  36 IC50  1 Kd

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 41 hits for monomerid = 50242271   

LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetApelin receptor(Human)
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 3.17E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford- Sanford-Burnham Medical Research Institute(SBMRI, San...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
PCBioAssay
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 110nMAssay Description:Inhibition of rat intestinal brush border membrane sucraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysosomal acid glucosylceramidase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 8.40E+4nMAssay Description:Inhibition of human lysosomal beta-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetGlycogen debranching enzyme(Rabbit)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 390nMAssay Description:Inhibition of rabbit muscle amylo-1,6-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysosomal alpha-glucosidase(Rat)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of rat intestinal maltase using moltose as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat intestinal sucrase using sucrose as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of rat intestinal isomaltase using isomaltase as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of rat intestinal brush border membrane isomaltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetAlpha-glucosidase(Aspergillus niger)
Savitribai Phule Pune University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 5.71E+4nMAssay Description:Inhibition of Aspergillus niger alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-mannosidase(Jack bean)
Savitribai Phule Pune University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 7.59E+4nMAssay Description:Inhibition of Canavalia ensiformis alpha-mannosidase using p-nitrophenyl-alpha-D-mannopyranoside as substrate preincubated for 1 hr followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMaltase-glucoamylase(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human intestinal maltase using maltose as substrate incubated for 30 mins and immediately heated for 2 mins by glucose oxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-mannosidase(Jack bean)
Savitribai Phule Pune University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataKd:  1.05E+5nMAssay Description:Inhibition of jack bean alpha-mannosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetMaltase-glucoamylase(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.54E+5nMAssay Description:Inhibition of alpha-glucosidase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Wistar rat small intestine sucrase after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 500nMAssay Description:Inhibition of sucrase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
University of Pune

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 3.79E+5nMAssay Description:Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of Wistar rat intestinal isomaltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetBeta-galactosidase(Bovine)
Savitribai Phule Pune University (Formerly University of Pune)

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of bovine liver beta-galactosidase using 10 mM p-nitrophenyl-beta-D-galactopyranoside as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetMaltase-glucoamylase(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human small intestine microsomal maltase using maltose as substrate incubated for 30 mins by glucose-oxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 430nMAssay Description:Inhibition of rat small intestinal sucrase using sucrose as substrate incubated for 30 mins by glucose-oxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2017
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of rat small intestinal isomaltase using isomaltose as substrate incubated for 30 mins by glucose-oxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2017
Entry Details Article
PubMed
TargetOligo-1,6-glucosidase IMA1(Baker's yeast)
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 9.90E+6nMAssay Description:Inhibition of baker's yeast alpha-glucosidase by 4-nitrophenolate-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of GCS by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMaltase-glucoamylase(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of maltase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLactase/phlorizin hydrolase(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of lactase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 590nMAssay Description:Inhibition of Wistar rat small intestine maltase after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of Wistar rat small intestine isomaltase after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of rat intestinal brush border membrane maltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysosomal alpha-glucosidase(Rat)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataKi:  460nMAssay Description:Competitive inhibition of rat intestinal maltase by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMaltase-glucoamylase(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-galactosidase(Bovine)
Savitribai Phule Pune University (Formerly University of Pune)

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition of bovine liver beta-galactosidase using 10 mM p-nitrophenyl-beta-D-galactopyranoside as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetAlpha-mannosidase(Jack bean)
Savitribai Phule Pune University

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataKi:  1.05E+5nMAssay Description:Inhibition of jack bean alpha-mannosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed