BDBM50242401 4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile::A-769662::CHEMBL512504

SMILES c1ccc(c(c1)c2ccc(cc2)c3csc4c3C(=C(C(=O)N4)C#N)O)O

InChI Key InChIKey=CTESJDQKVOEUOY-UHFFFAOYSA-N

Data  3 Kd  3 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50242401   

LigandPNGBDBM50242401(A-769662 | 4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6...)
Affinity DataEC50:  116nMAssay Description:Activation of rat AMPK-alpha-1-alpha-2beta-1-gamma-1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50242401(A-769662 | 4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6...)
Affinity DataKd:  487nMAssay Description:Binding affinity for full length human N-terminal His/BAP-tagged AMPK alpha1/beta1/gamma1 expressed in Escherichia coli BL21-CodonPlus by surface pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50242401(A-769662 | 4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6...)
Affinity DataEC50:  390nMAssay Description:Activation of human AMPK alpha2/beta1/gamma1 expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50242401(A-769662 | 4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6...)
Affinity DataKd:  510nMAssay Description:Binding affinity to human recombinant N-terminal AVI-tagged phosphorylated AMPK alpha1beta1gamma1 expressed in Escherichia coli BL21 cells after 1 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50242401(A-769662 | 4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6...)
Affinity DataKd:  1.45E+4nMAssay Description:Binding affinity to human recombinant N-terminal AVI-tagged phosphorylated AMPK alpha1beta2gamma1 expressed in Escherichia coli BL21 cells after 1 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50242401(A-769662 | 4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6...)
Affinity DataEC50:  800nMAssay Description:Activation of human AMPK alpha1/beta1/gamma1 expressed in baculovirus/Sf9 cells using SAMS peptide as substrate incubated for 15 mins by in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)