BDBM50246899 (S)-2-(3-((S)-1-carboxy-5-(4-iodobenzamido)pentyl)ureido)pentanedioic acid::CHEMBL510924::N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amino}pentyl]carbamoyl}-L-glutamic acid

SMILES c1cc(ccc1C(=O)NCCCC[C@@H](C(=O)O)NC(=O)N[C@@H](CCC(=O)O)C(=O)O)I

InChI Key InChIKey=ROXRILBFJQYPNZ-UHFFFAOYSA-N

Data  7 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50246899   

TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataKi:  0.00300nMAssay Description:Inhibition of antiTEV-tagged GCP2 extracellular portion (aa 44-750) (unknown origin) using folyl-di-L-glutamate as substrate by HPLC-based enzymatic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of PSMA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity to human recombinant PSMA (unknown origin) assessed as inhibition constant incubated for 60 mins in presence of NAAGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed