BDBM50255164 CHEMBL4096683

SMILES c1ccc(cc1)c2cc3c(ccc(c3[nH]2)C(=O)N)N[C@H]4CCCNC4

InChI Key InChIKey=AQEDGKFVSWOMSY-UHFFFAOYSA-N

Data  2 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50255164   

TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255164(CHEMBL4096683)
Affinity DataIC50: 31nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255164(CHEMBL4096683)
Affinity DataEC50:  53nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50255164(CHEMBL4096683)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed