BDBM50259376 3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-cyclobut-3-ene-1,2-dione::3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione::CHEMBL466496

SMILES C[C@@H](Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1

InChI Key InChIKey=MCBPNFWHHNJTGN-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50259376   

TargetAurora kinase B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IKKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 810nMAssay Description:Inhibition of RSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform gamma-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 250nMAssay Description:Inhibition of CK1-gamma1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 4.05E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 60nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of human recombinant MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50259376(3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino...)
Affinity DataIC50: 250nMAssay Description:Inhibition of CK1 using KRRRALS(p)VASLPGL as substrate after 40 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed