BDBM50260246 1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(3-methoxy-4-(thiophene-2-carbonyloxy)phenyl)cyclobutane-1,3-dicarboxylic acid::CHEMBL449327

SMILES CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)NC2(C(C(C2c3ccc(c(c3)OC)OC(=O)c4cccs4)(C(=O)O)NC(=O)c5ccc(cc5)NC(=O)OC(C)(C)C)c6ccc(c(c6)OC)OC(=O)c7cccs7)C(=O)O

InChI Key InChIKey=JSLFGFBQFKCNSQ-UHFFFAOYSA-N

Data  1 KI  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50260246   

TargetGlucagon-like peptide 1 receptor(Rat)
The National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260246(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Rat)
The National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260246(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)
Affinity DataEC50:  371nMAssay Description:Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Rat)
The National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260246(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)
Affinity DataEC50:  370nMAssay Description:Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Rat)
The National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260246(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Rat)
The National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260246(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Rat)
The National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260246(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Rat)
The National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260246(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)
Affinity DataIC50: 600nMAssay Description:Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Rat)
The National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260246(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)
Affinity DataIC50: 600nMAssay Description:Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Rat)
The National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260246(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)
Affinity DataEC50:  2.73E+3nMAssay Description:Agonist activity at rat GLP1 receptor expressed in HEK293 cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Rat)
The National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50260246(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)
Affinity DataKi:  1.47E+3nMAssay Description:Displacement of [125I]GLP1 from rat GLP1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed