BDBM50268016 CHEMBL4080860

SMILES COc1c2cc(cnc2[nH]n1)C#Cc3c(ccc(c3F)NS(=O)(=O)c4cccc(c4)Br)F

InChI Key InChIKey=PJGQKTLXZJMPIM-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50268016   

TargetMitogen-activated protein kinase kinase kinase 20(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50268016(CHEMBL4080860)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50268016(CHEMBL4080860)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild type GST-tagged recombinant human full-length B-RAF expressed in baculovirus expression system using Ser/Thr3 as substrate after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details Article
PubMed