BDBM50296256 7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL551052

SMILES CCCOCCn1c2cc(ncc2nc(NCCN2CCOCC2)c1=O)-c1ccc(OC)nc1

InChI Key InChIKey=OFRWMWHKNKWEHT-UHFFFAOYSA-N

Data  18 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50296256   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
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TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
8/30/2010
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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE9More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

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Date in BDB:
8/30/2010
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TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

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Date in BDB:
8/30/2010
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TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

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Date in BDB:
8/30/2010
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TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE7AMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE4CMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
Entry Details Article
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
Entry Details Article
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/26/2010
Entry Details Article
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
Entry Details Article
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
Entry Details Article
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE2More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
Entry Details Article
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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE1CMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
Entry Details Article
Copy Entry DOIPubMed
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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE1BMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
Entry Details Article
Copy Entry DOIPubMed
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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE1AMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
Entry Details Article
Copy Entry DOIPubMed
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
Entry Details Article
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TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: 346nMAssay Description:Inhibition of PDE11More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2010
Entry Details Article
Copy Entry DOIPubMed
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