BDBM50307137 (3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one::(Z)-5-Amino-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one::CHEMBL597181

SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1

InChI Key InChIKey=XYONNOXYJMPBMA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50307137   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307137((Z)-5-Amino-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylen...)
Affinity DataIC50: 630nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307137((Z)-5-Amino-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylen...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ABL by ELISA-based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307137((Z)-5-Amino-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylen...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307137((Z)-5-Amino-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylen...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed