BDBM50308247 CHEMBL1215855::ibogaine

SMILES CC[C@H]1C[C@@H]2C[C@@H]3[C@H]1[N@](C2)CCc4c3[nH]c5c4cc(cc5)OC

InChI Key InChIKey=HSIBGVUMFOSJPD-UHFFFAOYSA-N

Data  79 KI  19 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 98 hits for monomerid = 50308247   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 4.09E+3nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 7.60E+3nMAssay Description:pirenzepine forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 5.90E+3nMAssay Description:AF-DX384 forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 1.00E+5nMAssay Description:spiperone cloned .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetHistamine H1 receptor(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 1.00E+4nMAssay Description:pyrilamine forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetKappa-type opioid receptor(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 1.60E+4nMAssay Description:U69,593 forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetKappa-type opioid receptor(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 2.98E+4nMAssay Description:U69,593 forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetKappa-type opioid receptor(Mouse)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 1.38E+4nMAssay Description:U69,593 forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 2.10E+4nMAssay Description:U69,593 forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetMu-type opioid receptor(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 2.60E+4nMAssay Description:DAGO forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 1.00E+5nMAssay Description:CGS-19755 forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 3.20E+3nMAssay Description:dizocilpine forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 5.20E+3nMAssay Description:MK-801 forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 950nMAssay Description:Antagonist activity at human alpha3beta4 nAChRs expressed in HEK293 cells assessed as inhibition of (+/-)-epibatidine-induced Ca+2 influx incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at alpha4beta2 nAChR in HEK293 cells by voltage-clamp based electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 220nMAssay Description:Antagonist activity at recombinant alpha3beta4 nAChR in HEK293 cells by voltage-clamp based electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSynaptic vesicular amine transporter(Rat)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of rat VMAT2 transfected in HEK cells using FFN206 as fluorescent substrate preincubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 500nMAssay Description:Inhibition of human SERT transfected in HEK cells using APP+ as fluorescent substrate preincubated for 1 hr followed by substrate addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 4(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 5.05E+4nMAssay Description:TCP forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSigma intracellular receptor 2(Bos taurus)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-DTG from calf hippocampus sigma 2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]Ibogaine from human alpha3beta4 nAChRs expressed in HEK293 cells assessed as inhibition constant incubated for 2 hrs by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-DAGO from calf cortex MOR receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]-U69593 from calf cortex KOR receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMuscarinic receptor M1(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-pirenzepine from calf cortex Muscarinic M1 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  90nMAssay Description:Binding affinity to sigma-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  90.4nMAssay Description:DTG liver .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  201nMAssay Description:DTG + dextrallorphan liver .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  206nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Guinea pig)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  250nMAssay Description:DTG brain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSigma intracellular receptor 2(Bos taurus)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  400nMAssay Description:DTG hippocampus .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  549nMAssay Description:[125I]RTI-55 occipital cortex .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  549nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  1.01E+3nMAssay Description:MK-801 forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  1.11E+3nMAssay Description:MK-801 forebrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  1.19E+3nMAssay Description:MK-801 hippocampus .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  1.81E+3nMAssay Description:MK-801 cortex .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  1.97E+3nMAssay Description:MK-801 striatum .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  1.98E+3nMAssay Description:[125I]RTI-121 occipital cortex .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  1.98E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  1.98E+3nMAssay Description:MK-801 Thalamus + hypothalamus .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetMu-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2.00E+3nMAssay Description:DAGO cortex .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2.00E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetKappa-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2.08E+3nMAssay Description:U69,593 cortex .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetKappa-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2.20E+3nMAssay Description:U69,593 cortex .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2.22E+3nMAssay Description:MK-801 spinal cord .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2.46E+3nMAssay Description:MK-801 midbrain .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Bovine)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2.50E+3nMAssay Description:(+)-pentazocine caudate .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2.72E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic N-methyl D-aspartate 2A(Bovine)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  3.10E+3nMAssay Description:MK-801 cortex .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Oklahoma

LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  3.31E+3nMAssay Description:MK-801 cerebellum .More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
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