BDBM50324475 Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzyl)amide Bis-(trifluoroacetate)::CHEMBL1215083::CHEMBL1229259

SMILES [H]/N=C(/c1ccc(cc1)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCN/C(=N/[H])/N)NS(=O)(=O)Cc3ccccc3)\N

InChI Key InChIKey=QKFCYPKTTJCUSZ-UHFFFAOYSA-N

Data  12 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50324475   

TargetProthrombin(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  1.94nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor X(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlasma kallikrein(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  8.30nMAssay Description:Inhibition of plasma kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTransmembrane protease serine 11D(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  19nMAssay Description:Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTransmembrane protease serine 2(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPlasminogen(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  39nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  55nMAssay Description:Inhibition of human recombinant matriptase catalytic domain expressed in HEK293 cells after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  55nMAssay Description:Inhibition of matriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTransmembrane protease serine 6(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  170nMAssay Description:Inhibition of matriptase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTransmembrane protease serine 6(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  170nMAssay Description:Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetTransmembrane protease serine 6(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  190nMAssay Description:Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed