BDBM50326206 CHEMBL1243200::N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-(phenylamino)benzamide

SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Nc2ccccc2)cc1

InChI Key InChIKey=YRIZEPGWRQGUBO-UHFFFAOYSA-N

Data  17 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50326206   

TargetTyrosine-protein kinase JAK2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Jak2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK5 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKBalpha by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Erk1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PLK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p70s6k by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JNK2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BTK by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Jak3 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataEC50:  15nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Zap70 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IGFR1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EphB4 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed