BDBM50330422 CHEMBL4176772

SMILES c1cc(cc(c1)Nc2c3c([nH]n2)ncnc3Nc4cccc(c4)O)CN

InChI Key InChIKey=OUMZUIUUJCKLOT-UHFFFAOYSA-N

Data  1 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50330422   

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50330422(CHEMBL4176772)
Affinity DataKd:  5.00E+4nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50330422(CHEMBL4176772)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant complement factor D catalytic domain (unknown origin) using Z-Lys-thiobenzyl as substrate pretreated for 1 hr followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)