BDBM50331629 5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl)-1H-pyrazole-4-carboxamide::CHEMBL1290746

SMILES Cc1ccc(cc1NC(=O)c1cnn(c1N)-c1ccccc1F)C(=O)Nc1ccon1

InChI Key InChIKey=HFTDLOVSQHYBFJ-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50331629   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Tyk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of human ERG by flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PKCzetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PKAbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of DGATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Jak3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IGF-1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of STAT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of BtkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50331629(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed