BDBM50357803 CHEMBL1916113

SMILES Cc1cnccc1c2nc(c3n2c4cc(cc(c4nc3C)OC)F)C

InChI Key InChIKey=JGRMMBRYUDVUAI-UHFFFAOYSA-N

Data  13 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50357803   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetAdenosine receptor A1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 150nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetAdenosine receptor A2a(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 5.05E+3nMAssay Description:Inhibition of adenosine A2A receptorMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bovine)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 108nMAssay Description:Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357803(CHEMBL1916113)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL