BDBM50361647 CHEMBL1940244

SMILES CC(C)n1cc(c2c1ncnc2N)C(=O)c3cncc(n3)NCCc4cccnc4

InChI Key InChIKey=WMUOCKJUZCEMCY-UHFFFAOYSA-N

Data  2 KI

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50361647   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50361647(CHEMBL1940244)Copy SMILESCopy InChI

Affinity DataKi:  35nMAssay Description:Inhibition of PDK1-mediated AKT1 phosphorylation at T308 in human H460 cells after 2 hrs by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/22/2012
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Mouse)
Pfizer

Curated by ChEMBL

LigandBDBM50361647(CHEMBL1940244)Copy SMILESCopy InChI

Affinity DataKi:  250nMAssay Description:Inhibition of mouse PI3Kalpha after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/22/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL