BDBM50374608 CHEMBL410295

SMILES Cc1cccc(c1N2c3nc4ccccc4n3-c5c(cnc(n5)Nc6ccc(cc6)N7CCN(CC7)C)C2=O)C

InChI Key InChIKey=BHJJWVDKNXABFS-UHFFFAOYSA-N

Data  21 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50374608   

TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 150nMAssay Description:Inhibition of JAK3 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 540nMAssay Description:Inhibition of b-Raf by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 750nMAssay Description:Inhibition of Tie-2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Itk by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 200nMAssay Description:Inhibition of Syk by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38-alpha by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of JNK2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 560nMAssay Description:Inhibition of c-Kit by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 410nMAssay Description:Inhibition of Btk by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of JNK3 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Tyk2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of ZAP-70 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 21nMAssay Description:Inhibition of Lyn by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 120nMAssay Description:Inhibition of Src by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 7nMAssay Description:Inhibition of Lck by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human T-cell receptor zeta chain phosphorylation in Jurkat cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRibosomal protein S6 kinase alpha-5(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MSK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK5 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Erk1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed