BDBM50388112 CHEMBL2058971

SMILES c1ccc2c(c1)c(cc(n2)C(F)(F)F)N3CCN(CC3)[C@H]4C[C@H](NC4)C(=O)N5CCSC5

InChI Key InChIKey=JWKZKADFQDTDIU-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50388112   

TargetDipeptidyl peptidase 9(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50388112(CHEMBL2058971)
Affinity DataIC50: 105nMAssay Description:Inhibition of human recombinant DPP9 using Gly-Pro-MCA as substrate after 30 mins by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50388112(CHEMBL2058971)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50388112(CHEMBL2058971)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50388112(CHEMBL2058971)
Affinity DataIC50: 72.4nMAssay Description:Inhibition of human recombinant DPP8 using Gly-Pro-MCA as substrate after 30 mins by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50388112(CHEMBL2058971)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of DPP4 in human plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)