BDBM50389241 CHEMBL1990583

SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12

InChI Key InChIKey=DASFSPDIWCMVRW-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50389241   

TargetMitogen-activated protein kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 296nMAssay Description:Inhibition of Erk2 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of EGFR in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 5.34E+3nMAssay Description:Inhibition of Gsk3alpha in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 8.14E+3nMAssay Description:Inhibition of Jak3 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Alk1 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type IV(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Camk4 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Jak2 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Jnk1 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Met in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Rock2 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Chk1 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 340nMAssay Description:Inhibition of Irak4 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 566nMAssay Description:Inhibition of lck in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Flt3 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of KDR in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of TrkA in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Src in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 9nMAssay Description:Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 3nMAssay Description:Inhibition of Aurora A kinase in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 3nMAssay Description:Inhibition of Aurora B kinase in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: 3nMAssay Description:Inhibition of Plk4 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed