BDBM50394681 CHEMBL2165620

SMILES c1cc(ncc1C(=O)O)NC(=O)[C@H](CC2CCCC2)n3cc(nc3)C(F)(F)F

InChI Key InChIKey=GKMLFBRLRVQVJO-UHFFFAOYSA-N

Data  3 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50394681   

TargetHexokinase-4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394681(CHEMBL2165620)
Affinity DataEC50:  6.90E+3nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as stimulation of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394681(CHEMBL2165620)
Affinity DataEC50:  90nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394681(CHEMBL2165620)
Affinity DataEC50:  190nMAssay Description:Induction of glucokinase translocation from nucleus to cytoplasm in cryopreserved rat hepatocytes after 1 hr by Hoechst staining-based fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)