BDBM50425831 CHEMBL2312301

SMILES COc1ccccc1CNc2ncc(c(n2)NC3CCCC3)C(=O)NCCCN4CCCC4=O

InChI Key InChIKey=ZXZLVQGNVOKCAS-UHFFFAOYSA-N

Data  24 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50425831   

TargetInsulin receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetTyrosine-protein kinase receptor TYRO3(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 400nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetP-selectin(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of P-selectin aggregation in platelet surface (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetTyrosine-protein kinase receptor TYRO3(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 400nMAssay Description:Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetTyrosine-protein kinase ABL1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetRAC-alpha serine/threonine-protein kinase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetSerine/threonine-protein kinase Chk2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetCasein kinase I isoform delta(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKKbeta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKKi (unknown origin)More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetMitogen-activated protein kinase 1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPK1/ERK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
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Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetSerine/threonine-protein kinase pim-2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetProtein kinase C zeta type(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PKCzeta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetSerine/threonine-protein kinase Sgk1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SGK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 4.51E+3nMAssay Description:Inhibition of HGFR (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase receptor UFO(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase Mer(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 4.68E+3nMAssay Description:Inhibition of Mer (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425831(CHEMBL2312301)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL