BDBM50427040 CHEMBL2322207

SMILES Cc1ccc(cc1)S(=O)(=O)N[C@@H]2C[C@@H](CNC2)C(=O)NCC3(c4ccccc4Oc5c3cccc5)CCCCOC

InChI Key InChIKey=LBPUIWQYAGTBDC-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50427040   

TargetRenin(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched (RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: 25nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant BACE1 expressed in baculovirus-infected SF9 cells using fluorescence-quenched RE(EDANS)-EVNLDAEF-K(DABSYL)-R as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: 4nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant BACE2 expressed in baculovirus-infected SF9 cells using fluorescence-quenched RE(EDANS)-EVNLDAEF-K(DABSYL)-R as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCathepsin E(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant cathepsin E expressed in Escherichia coli using fluorescence-quenched Ac-E-D(EDANS)-KPILFFRLG-K(Dabcyl)-E-Amid as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCathepsin D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant cathepsin D expressed in baculovirus-infected SF9 cells using fluorescence-quenched Ac-E-D(EDANS)-KPILFFRLG-K(Dabcyl)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGastricsin(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant pepsin C expressed in Escherichia coli using fluorescence-quenched Dabcyl-E-R-Nle-F-L-S-F-P-EDANS as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed