BDBM50430287 CHEMBL2333444

SMILES CN1c2ccc(NCc3ccc(cc3)C(C)(C)C)cc2-c2c(cnn2C)S1(=O)=O

InChI Key InChIKey=AVFJKWOKOZKXRX-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50430287   

TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50430287(CHEMBL2333444)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50430287(CHEMBL2333444)
Affinity DataIC50: 640nMAssay Description:Allosteric inhibition of FAK (unknown origin) using poly-(GT)-biotin and 0.5 uM of ATP preincubated for 60 mins measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50430287(CHEMBL2333444)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of intracellular FAK autophosphorylation in human PC3 M-luc cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50430287(CHEMBL2333444)
Affinity DataIC50: 2.20E+3nMAssay Description:Allosteric inhibition of FAK (unknown origin) using poly-(GT)-biotin and 0.5 uM of ATP preincubated for 5 mins measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50430287(CHEMBL2333444)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50430287(CHEMBL2333444)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50430287(CHEMBL2333444)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Akt1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50430287(CHEMBL2333444)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50430287(CHEMBL2333444)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50430287(CHEMBL2333444)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Pyk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed