BDBM50431079 CHEMBL2338785::US10202399, Example 9::US9180122, 27::US9212147, 9

SMILES c1ccc(cc1)CCC2=CNC(=O)C(=C2)O

InChI Key InChIKey=XUXZMSAUXVFNPQ-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50431079   

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431079(CHEMBL2338785 | US9180122, 27 | US9212147, 9 | US1...)
Affinity DataIC50: 140nMAssay Description:The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431079(CHEMBL2338785 | US9180122, 27 | US9212147, 9 | US1...)
Affinity DataIC50: 3.90nMpH: 7.5 T: 2°CAssay Description:The DAAO inhibitory activity was measured by assaying the amount of hydrogen peroxide (H2O2) produced by reacting DAAO protein with flavin adenine di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431079(CHEMBL2338785 | US9180122, 27 | US9212147, 9 | US1...)
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:This test was performed by partially modifying the method of Philip et. al. (J. Biomol. Screen. Vol. 11, pp 481-487, 2006). HEK293 cells that stably ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431079(CHEMBL2338785 | US9180122, 27 | US9212147, 9 | US1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of DAAO (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431079(CHEMBL2338785 | US9180122, 27 | US9212147, 9 | US1...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431079(CHEMBL2338785 | US9180122, 27 | US9212147, 9 | US1...)
Affinity DataIC50: 3.90nMAssay Description:The DAAO inhibitory activity was measured by assaying the amount of hydrogen peroxide (H2O2) produced by reacting DAAO protein with flavin adenine di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)