BDBM50445062 CHEMBL3098771

SMILES C/C(=C\C(=O)O)/C=C/C=C(/C)\C=C\1/CCCc2c1cccc2

InChI Key InChIKey=PPGNMFUMZSAZCW-UHFFFAOYSA-N

Data  1 IC50  4 Kd  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50445062   

TargetRetinoic acid receptor RXR-alpha(Human)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50445062(CHEMBL3098771)
Affinity DataKd:  1.88E+3nMAssay Description:Agonist activity at human RXR-alpha-ligand binding domain homodimers assessed as coactivator recruitment by measuring GRIP1 binding to receptor by is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50445062(CHEMBL3098771)
Affinity DataKd:  33nMAssay Description:Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Rat)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50445062(CHEMBL3098771)
Affinity DataEC50:  400nMAssay Description:Agonist activity at RXR-alpha in rat R3KE cells infected with oncogene KLF4-ER assessed as inhibition of KLF4-mediated oncogenic transformationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50445062(CHEMBL3098771)
Affinity DataEC50:  820nMAssay Description:Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50445062(CHEMBL3098771)
Affinity DataKd:  1.33E+3nMAssay Description:Binding affinity to human RXRalpha LBD after 15 mins by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Rat)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50445062(CHEMBL3098771)
Affinity DataEC50:  820nMAssay Description:Agonist activity at RXRalpha in rat RK3E cells assessed as transcriptional activation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50445062(CHEMBL3098771)
Affinity DataKd:  29nMAssay Description:Binding affinity to human RXRalpha LBD (T225 to T462 residues) by fluorescence quenching assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50445062(CHEMBL3098771)
Affinity DataEC50:  850nMAssay Description:Agonist activity at human GAL4-fused RXRalpha LBD (T225 to T462 residues) expressed in HEK293 cells incubated for 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50445062(CHEMBL3098771)
Affinity DataIC50: 284nMAssay Description:Inhibition of RXRalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)