BDBM50450625 CHEMBL4160522

SMILES c1cc2ccsc2c(c1)C(=O)Nc3cc(ccc3Cl)C(=O)NO

InChI Key InChIKey=FRUVCGVXUWSDQY-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50450625   

TargetHistone deacetylase 6(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50450625(CHEMBL4160522)
Affinity DataIC50: 53nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus infected Sf9 insect cells using Z(Ac)Lys-AMC as substrate by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone deacetylase 8(Blood fluke)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50450625(CHEMBL4160522)
Affinity DataIC50: 97nMAssay Description:Inhibition of Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 8(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50450625(CHEMBL4160522)
Affinity DataIC50: 155nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50450625(CHEMBL4160522)
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of C-terminal FLAG/His-tagged full length human HDAC1 expressed in baculovirus infected Sf9 insect cells using Z(Ac)Lys-AMC as substrate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed