BDBM50511652 CHEMBL4572689::US12110286, Example 1i

SMILES CC(C)(CCN1c2cc(ccc2N(C1=O)C)Nc3ccnc(c3C#N)Cl)O

InChI Key InChIKey=MSNMXJGUICGVME-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50511652   

TargetB-cell lymphoma 6 protein(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50511652(CHEMBL4572689 | US12110286, Example 1i)
Affinity DataIC50: 860nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50511652(CHEMBL4572689 | US12110286, Example 1i)
Affinity DataIC50: 860nMAssay Description:Inhibition of human BCL6 BTP domain measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50511652(CHEMBL4572689 | US12110286, Example 1i)
Affinity DataIC50: 1.70E+3nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained either 1 nM (data in table 1b) or 10 nM (data in table 1a) Trx-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50511652(CHEMBL4572689 | US12110286, Example 1i)
Affinity DataIC50: 832nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained either 1 nM (data in table 1b) or 10 nM (data in table 1a) Trx-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)