BDBM50512964 CHEMBL4574669

SMILES CN1C[C@H](C[C@H](C1)NC2=Nc3cc[nH]c3C(=O)N2C)c4ccc5c(c4)OCCO5

InChI Key InChIKey=PUFPGLSWMMJNSE-UHFFFAOYSA-N

Data  2 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50512964   

TargetHistone acetyltransferase KAT2B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50512964(CHEMBL4574669)
Affinity DataKd:  78nMAssay Description:Binding affinity to human N-terminal His-tagged PCAF by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50512964(CHEMBL4574669)
Affinity DataKd:  105nMAssay Description:Binding affinity to human N-terminal His-tagged GCN5 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNucleosome-remodeling factor subunit BPTF(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50512964(CHEMBL4574669)
Affinity DataKd:  917nMAssay Description:Binding affinity to human N-terminal His-tagged FALZ by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50512964(CHEMBL4574669)
Affinity DataIC50: 7nMAssay Description:Inhibition of biotinylated peptide binding to human GST-tagged PCAF bromodomain expressed in Escherichia coli Rosetta (DE3) measured after 15 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50512964(CHEMBL4574669)
Affinity DataIC50: 118nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to N-terminal Nano luciferase-fused full-length PCAF (unknown origin) expressed in HEK293T cells co-ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed