BDBM50519465 CHEMBL4466522

SMILES CN1c2c(n(c(n2)Oc3cccc(c3)OC(F)(F)F)Cc4ccc(cc4)Cl)C(=O)N(C1=O)CCCO

InChI Key InChIKey=PRJHEJGMSOBHTO-UHFFFAOYSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50519465   

TargetShort transient receptor potential channel 4(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50: 0.0120nMAssay Description:Inhibition of human TRPC4 expressed in HEK293 cells assessed as reduction in sphingosine-1-phosphate-induced current at -100 mV by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 5(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fluo-4AM dye b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 1/5(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human TRPC5/human TRPC1 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 4(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human TRPC4 expressed in HEK293 cells assessed as reduction in sphingosine-1-phosphate-induced current at +100 mV by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 1/4(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50: 0.0330nMAssay Description:Inhibition of human TRPC4/human TRPC1 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 4(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of human TRPC4 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fluo-4AM dye b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)