BDBM50547964 CHEMBL4783351::US20250074919, Example CA4948

SMILES Cc1cc(ccn1)-c1nc(co1)C(=O)Nc1cc2oc(nc2nc1N1CC[C@@H](O)C1)N1CCOCC1

InChI Key InChIKey=SJHNWSAWWOAWJH-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50547964   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged human IRAK4 expressed in baculovirus infected sf9 cells using biotinylated histone H3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 514nMAssay Description:Inhibition of IRAK4 in human THP-1 cells assessed as inhibition of LTA-induced TNF-alpha production preincubated for 60 mins followed by LTA stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 989nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of TLR2-mediated LTA-induced IL-6 release preincubated for 1 hr followed by LTA stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of IL-1R-mediated IL-1beta-induced IL-6 release preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 696nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of TLR5-mediated FLA-ST-induced IL-6 release preincubated for 1 hr followed by FLA-ST...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 270nMAssay Description:Inhibition of IRAK4 in human MV4-11 cells assessed as modulation of phospho-IRAK1 level by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 115nMAssay Description:Table 2: Prepare Ix kinase base buffer and stop buffer for testing kinases: (1) base buffer: 50 mM HEPES (pH 7.5), 0.0015% Brij-35; (2) stop buffer: ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2025
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 33nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50547964(CHEMBL4783351 | US20250074919, Example CA4948)
Affinity DataIC50: 115nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed