BDBM50548192 CHEMBL4749141::US20240300941, Compound A7

SMILES Nc1ncc(cc1OCc1ccncc1)-c1cnc(s1)C1CCNCC1

InChI Key InChIKey=HSEGDFMLRPWOHH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50548192   

LigandPNGBDBM50548192(CHEMBL4749141 | US20240300941, Compound A7)
Affinity DataIC50: 434nMAssay Description:Inhibition of GLK in human T cells assessed as reduction in PKCtheta phosphorylation by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50548192(CHEMBL4749141 | US20240300941, Compound A7)
Affinity DataIC50: 278nMAssay Description:Inhibition of GLK (unknown origin) transfected in human 293T cells co-transfected with GFP-fused PKCtheta assessed as reduction in PKCtheta phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50548192(CHEMBL4749141 | US20240300941, Compound A7)
Affinity DataIC50: 3nMAssay Description:Inhibition of GLK (unknown origin) by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Zhuhai Yufan Biotechnologies

US Patent
LigandPNGBDBM50548192(CHEMBL4749141 | US20240300941, Compound A7)
Affinity DataIC50: 100nMAssay Description:The buffer used in the enzyme assay contains 5 mM MOPS (pH=7.2), 2.5 mM β-Glycerol Phosphate, 0.4 mM EDTA, 1 mM EGTA, 0.05 mM DTT, 5 mM MgCl2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent