BDBM50558426 CHEMBL4788348

SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C=C4[C@@]3(CC[C@@H](C4)O)C)O)C

InChI Key InChIKey=BQMSKLCEWBSPPY-UHFFFAOYSA-N

Data  2 KI  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50558426   

TargetG-protein coupled receptor 183(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50558426(CHEMBL4788348)
Affinity DataEC50:  0.0320nMAssay Description:Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 183(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50558426(CHEMBL4788348)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at Go2-q-coupled rat EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 183(Mouse)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50558426(CHEMBL4788348)
Affinity DataEC50:  0.702nMAssay Description:Agonist activity at Go2-q-coupled mouse EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 183(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50558426(CHEMBL4788348)
Affinity DataEC50:  0.140nMAssay Description:Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxysterol-binding protein 1(Homo sapiens)
University of Oklahoma

Curated by ChEMBL
LigandPNGBDBM50558426(CHEMBL4788348)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]-25-OHC from human OSBP overexpressed in HEK293T cell lysate assessed as inhibition constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetOxysterol-binding protein 2(Human)
University of Oklahoma

Curated by ChEMBL
LigandPNGBDBM50558426(CHEMBL4788348)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]-25-OHC from human ORP4 overexpressed in HEK293T cell lysate assessed as inhibition constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed