BDBM50577646 CHEMBL4845770

SMILES Cc1nc2n(ncc2cc1Nc1c(F)cccc1Cl)-c1csc(c1)C(=O)NC1COC1

InChI Key InChIKey=KDMADGZAPDHVHE-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50577646   

TargetMitogen-activated protein kinase 10(Human)
Reaction Biology

Curated by ChEMBL
LigandPNGBDBM50577646(CHEMBL4845770)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK3alpha1 (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Reaction Biology

Curated by ChEMBL
LigandPNGBDBM50577646(CHEMBL4845770)
Affinity DataIC50: 387nMAssay Description:Inhibition of JNK1 (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Reaction Biology

Curated by ChEMBL
LigandPNGBDBM50577646(CHEMBL4845770)
Affinity DataIC50: 74nMAssay Description:Inhibition of JNK2 (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Reaction Biology

Curated by ChEMBL
LigandPNGBDBM50577646(CHEMBL4845770)
Affinity DataIC50: 106nMAssay Description:Inhibition of p38 alpha (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Reaction Biology

Curated by ChEMBL
LigandPNGBDBM50577646(CHEMBL4845770)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated Qpatch electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Reaction Biology

Curated by ChEMBL
LigandPNGBDBM50577646(CHEMBL4845770)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) by titration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Reaction Biology

Curated by ChEMBL
LigandPNGBDBM50577646(CHEMBL4845770)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) by titration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Reaction Biology

Curated by ChEMBL
LigandPNGBDBM50577646(CHEMBL4845770)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CK1E using KRRRAL[pS]VASLPGL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Reaction Biology

Curated by ChEMBL
LigandPNGBDBM50577646(CHEMBL4845770)
Affinity DataIC50: 247nMAssay Description:Inhibition of human DDR1 using KKSRGDYMTMQIG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Reaction Biology

Curated by ChEMBL
LigandPNGBDBM50577646(CHEMBL4845770)
Affinity DataIC50: 110nMAssay Description:Inhibition of human p38alpha using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed