BDBM50579217 CHEMBL4871593

SMILES CCC1(O)CCc2ccc(nc12)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12

InChI Key InChIKey=OXTSYWDBUVRXFF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50579217   

TargetWee1-like protein kinase(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579217(CHEMBL4871593)
Affinity DataIC50: 3.90nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579217(CHEMBL4871593)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579217(CHEMBL4871593)
Affinity DataIC50: 60nMAssay Description:Inhibition of EGFR d747-749/A750P mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 19(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579217(CHEMBL4871593)
Affinity DataIC50: 59nMAssay Description:Inhibition of YSK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579217(CHEMBL4871593)
Affinity DataIC50: 227nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579217(CHEMBL4871593)
Affinity DataIC50: 40nMAssay Description:Inhibition of PLK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579217(CHEMBL4871593)
Affinity DataIC50: 70nMAssay Description:Inhibition of PLK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Zentalis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50579217(CHEMBL4871593)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed