BDBM50581143 CHEMBL5077648

SMILES Cn1c(ccn1)C(=O)N[C@@H](Cc2ccccc2F)C(=O)Nc3ccc(cc3)CCNC(=O)CC4(CCCC4)CC(=O)N(C)C

InChI Key InChIKey=VWRXSIAIHJZTCV-UHFFFAOYSA-N

Data  1 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50581143   

TargetInterleukin-17A(Human)
Fidelta

Curated by ChEMBL
LigandPNGBDBM50581143(CHEMBL5077648)
Affinity DataKd: <660nMAssay Description:Binding affinity to IL-17A (unknown origin) measured by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-17A(Human)
Fidelta

Curated by ChEMBL
LigandPNGBDBM50581143(CHEMBL5077648)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of IL-17A (unknown origin) measured by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-17A(Human)
Fidelta

Curated by ChEMBL
LigandPNGBDBM50581143(CHEMBL5077648)
Affinity DataKd:  660nMAssay Description:Binding affinity to biotinylated Bap-tagged human IL-17A assessed as dissociation constant by SPR binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)